Why the study?
Does age influence the haemodynamic, renal, and cGMP responses to a bolus dose of atrial natriuretic factor in healthy volunteers?
Population
28 healthy volunteers, divided into an elderly group and a young group.
Comparison
Human atrial natriuretic factor 33 micrograms… vs Young healthy volunteers receiving the same…
Design
Other
Authors
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Supports age-matched controls in ANF studies; leaves open clinical relevance for elderly patients.
Does age influence the haemodynamic, renal, and cGMP responses to a bolus dose of atrial natriuretic factor in healthy volunteers?
Sensitivity to atrial natriuretic factor increases with age, resulting in greater haemodynamic and renal responses, which underscores the necessity of using age-matched controls in clinical studies of ANF.
Heim et al. (1989) studied this question.