Why the study?
Do blood pressure, age, heart rate, or sex influence plasma concentrations of ANF and cGMP in healthy individuals?
Do blood pressure, age, heart rate, or sex influence plasma concentrations of ANF and cGMP in healthy individuals?
In healthy individuals, plasma ANF and cGMP concentrations are not significantly influenced by blood pressure, age, heart rate, or sex, although ANF increases during blood donation.
ANF and cGMP levels independent of BP, age, HR, sex in healthy individuals; supports unbiased biomarker use but observational data leaves clinical relevance open.
The significance of increased atrial natriuretic factor (ANF) in relation to blood pressure and age is still controversial. We investigated the influence of blood pressure, age, and some other variables on ANF and its putative second messenger, cGMP. Samples for ANF and cGMP detection were taken from 124 ostensibly healthy individuals who were donating blood. Samples were also collected from 27 volunteers before and after blood donation, to study the influence of bleeding. During blood donation, ANF increased from 78.9 to 87.4 ng/L (P = 0.0035), whereas cGMP remained unchanged. ANF concentrations in 124 healthy individuals, corrected for the influence of bleeding, were 61.5 (SD 26.1) ng/L, with a 95% confidence interval of 10.0 to 112.1 ng/L. Mean cGMP concentrations in plasma were 2.9 (SD 1.45) nmol/L, with a 95% confidence interval of 0.4 to 5.75 nmol/L. Multivariance analysis revealed no significant influence of blood pressure, age, heart rate, or sex on concentrations of either ANF or cGMP in plasma.
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Wencker et al. (1989) studied this question.
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