Mechanically disrupted cardiac muscle fibers release intracellular calcium in response to specific chemical stimuli, similar to skinned skeletal muscle fibers.
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Skinned cardiac fibers show calcium release like skeletal muscle; extends basic mechanisms but leaves open translation to intact myocardium.
In cardiac muscle fibers which have had their sarcolemma disrupted intracellular stores of calcium ions can be released by the same chemical stimuli which cause their release from the sarcoplasmic reticulum of skinned skeletal muscle fibers. These stimuli are increases in calcium or caffeine concentrations and substitution of chloride for propionate or sodium for potassium in solutions bathing the fibers.
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Kerrick et al. (1974) studied this question.
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