Key result
A single-pill combination of amlodipine and valsartan lowers blood pressure significantly more than either component alone and reduces the incidence of amlodipine-induced edema.
Why the study?
Does a single-pill combination of amlodipine and valsartan improve blood pressure lowering and tolerability compared to monotherapy in patients with hypertension?
Does a single-pill combination of amlodipine and valsartan improve blood pressure lowering and tolerability compared to monotherapy in patients with hypertension?
The single-pill combination of amlodipine and valsartan is an effective and well-tolerated option for initial or second-line therapy in hypertension, offering superior blood pressure control and reduced edema compared to monotherapy.
May support amlodipine/valsartan single-pill use in hypertension; leaves open confirmation by randomized trials.
Combination therapy is increasingly recommended for selected patients with hypertension to facilitate prompt attainment and maintenance of goal blood pressure (BP). Single-pill combination therapy simplifies treatment and optimizes long-term compliance. Amlodipine, a dihydropyridine calcium antagonist, and valsartan, an angiotensin receptor blocker, are well-established antihypertensive agents with complementary mechanisms of action. This combination lowers BP significantly more than either of its components, and valsartan reduces the incidence of dose-related amlodipine-induced edema. Rigorous clinical trial data have proven the BP-lowering efficacy and high tolerability of the amlodipine/valsartan combination in patients with moderate to severe hypertension as well as other difficult-to-treat populations. Amlodipine/valsartan is indicated as initial therapy in patients who are unlikely to be controlled with a single drug and as second-line therapy in patients not responding adequately to monotherapy.
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Flack et al. (2009) conducted a review in hypertension. Single-pill combination of amlodipine and valsartan vs. monotherapy (amlodipine or valsartan) was evaluated. A single-pill combination of amlodipine and valsartan lowers blood pressure significantly more than either component alone and reduces the incidence of amlodipine-induced edema.
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