Key result
An 8-week treatment with a fixed-dose combination of amlodipine and valsartan normalized blood pressure in 85.2% of patients on the 10/160 mg dose and 78.4% on the 5/160 mg dose.
Why the study?
Does a fixed-dose combination of amlodipine and valsartan improve blood pressure control in hypertensive patients?
Population
Hypertensive patients (n=748 in the cited trial)
Design
Review
Follow-up
8 weeks
Authors
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May support BP control with amlodipine-valsartan combinations; leaves open need for randomized confirmation.
RCT (n=748)
randomized
Does a fixed-dose combination of amlodipine and valsartan improve blood pressure control in hypertensive patients?
Absolute Event Rate: 85.2% vs 78.4%
A fixed-dose combination of amlodipine and valsartan provides highly effective blood pressure control while mitigating amlodipine-induced peripheral edema.
Bernard Waeber (2009) conducted an RCT in hypertension (n=748). Amlodipine and valsartan fixed-dose combination vs. Amlodipine and valsartan 5/160 mg was evaluated on Normalized blood pressure (<140/90 mmHg). An 8-week treatment with a fixed-dose combination of amlodipine and valsartan normalized blood pressure in 85.2% of patients on the 10/160 mg dose and 78.4% on the 5/160 mg dose.
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