Population
Aortic tissue isolated from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats
Comparison
Chronic treatment with angiotensin converting… vs Untreated spontaneously hypertensive rats and…
Design
Preclinical
Authors
Loading...
Supports calcium-mediated vascular effects of ACE inhibition in SHR; leaves open translation to human hypertension mechanisms.
Chronic ACE inhibition reduces increased cytosolic free calcium and vascular tone in spontaneously hypertensive rats, suggesting a mechanism for its antihypertensive effect.
Sada et al. (1990) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: