Key result
The T1 MOLLI 5(3)3 acquisition scheme yielded higher native myocardial T1 values compared to the 4(1)3(1)2 scheme (1017 vs 956 ms; mean difference -61 ms; p<0.0001).
Why the study?
The study was conducted to systematically compare two MOLLI T1 mapping sequences and their impact on native myocardial T1, post-contrast T1, and extracellular volume.
Does the T1 MOLLI 5(3)3 acquisition scheme provide accurate myocardial T1 values native and post-contrast compared to the 4(1)3(1)2 scheme in patients with cardiomyopathies?
Population
200 patients prospectively included for 1.5 T CMR for cardiomyopathy work-up
Comparison
MOLLI 5(3)3 acquisition scheme vs 4(1)3(1)2 acquisition scheme
Design
Prospective observational study
Authors
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T1 values vary by MOLLI scheme; cautions against cross-protocol comparisons and leaves open need for standardization.
Observational (n=163)
Does the T1 MOLLI 5(3)3 acquisition scheme provide accurate myocardial T1 values native and post-contrast compared to the 4(1)3(1)2 scheme in patients with cardiomyopathies?
Mean Difference: -61
Absolute Event Rate: 1017% vs 956%
p-value: p=< 0.0001
The T1 MOLLI 5(3)3 acquisition scheme provides reliable estimation of myocardial T1 for both native and post-contrast scans at 1.5 T, whereas the 4(1)3(1)2 scheme should be restricted to post-contrast scans.
Krumm et al. (2022) conducted an observational in Ischemic or non-ischemic cardiomyopathies (n=163). T1 mapping MOLLI 5(3)3 acquisition scheme vs. T1 mapping MOLLI 4(1)3(1)2 acquisition scheme was evaluated on Native myocardial T1 values (mean intraindividual difference -61 ms, p=< 0.0001). The T1 MOLLI 5(3)3 acquisition scheme yielded higher native myocardial T1 values compared to the 4(1)3(1)2 scheme (1017 vs 956 ms; mean difference -61 ms; p<0.0001).
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