Key result
MOLLI significantly underestimated myocardial T1 values compared to SASHA in healthy volunteers at baseline (935.5 vs 1175.2 ms) and post-gadolinium, consistent with T2-dependent errors.
Why the study?
Does the MOLLI sequence underestimate T1 values compared to SASHA and IR-SE in phantoms and healthy volunteers?
Population
14 NiCl2 agarose phantoms and 10 healthy volunteers (5 male, mean age 28.8±6.6 years)
Comparison
MOLLI T1 mapping sequence vs SASHA technique and gold-standard…
Design
Preclinical
Authors
Loading...
Urges caution with MOLLI T1 values in practice; leaves open sequence standardization for quantitative CMR.
Cross-Sectional (n=10)
Does the MOLLI sequence underestimate T1 values compared to SASHA and IR-SE in phantoms and healthy volunteers?
Absolute Event Rate: 935.5% vs 1175.2%
p-value: p=<0.01
MOLLI significantly underestimates T1 values in shorter T2 tissue-like phantoms and in-vivo compared to SASHA, which shows better agreement with gold-standard measurements.
Chow et al. (2012) conducted a cross-sectional in Healthy (n=10). MOLLI T1 mapping vs. SASHA T1 mapping was evaluated on Baseline myocardial T1 value (ms) (p=<0.01). MOLLI significantly underestimated myocardial T1 values compared to SASHA in healthy volunteers at baseline (935.5 vs 1175.2 ms) and post-gadolinium, consistent with T2-dependent errors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: