March 27, 2001CirculationOpen Access

Aspirin (5 mmol/L) Inhibits Leukocyte Attack and Triggered Reactive Cell Proliferation in a 3D Human Coronary In Vitro Model

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Why the study?

Does aspirin inhibit leukocyte adhesion, chemotaxis, and smooth muscle cell proliferation in a 3D human coronary in vitro model?

Population

3D human coronary in vitro model of leukocyte attack using human coronary endothelial cells, human coronary…

Comparison

Aspirin (1, 2, 5, and 10 mmol/L) vs Control (no aspirin)

Design

Preclinical

Authors

RVRainer VoisardBundeswehrkrankenhaus RFRobert FischerUniversität Ulm MOMarkus OßwaldUniversität Ulm

Discussion

Member takes

Implication

In vitro aspirin effects are hypothesis-generating; should not change clinical practice pending human studies.

Structured PICO

Does aspirin inhibit leukocyte adhesion, chemotaxis, and smooth muscle cell proliferation in a 3D human coronary in vitro model?

Population

3D human coronary in vitro model of leukocyte attack (3DLA model) using human coronary endothelial cells (HCAEC), human coronary media smooth muscle cells (HCMSMC), and human monocytes or CD4(+) lymphocytes

Intervention

Aspirin (1, 2, 5, and 10 mmol/L)

Comparator

Control (no aspirin)

Outcome

Adhesion and chemotaxis of leukocytes and reactive proliferative response of smooth muscle cellssurrogate

High-dose aspirin (5 mmol/L) significantly inhibits leukocyte adhesion, chemotaxis, and smooth muscle cell proliferation in an in vitro human coronary model.

Cite This Study

Voisard et al. (2001) studied this question.

synapsesocial.com/papers/6a71b61efebe604dd70a3ec8 https://doi.org/10.1161/01.cir.103.12.1688

Topics

Coronary artery disease

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Aspirin (5 mmol/L) Inhibits Leukocyte Attack and Triggered Reactive Cell Proliferation in a 3D Human Coronary In Vitro Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Aspirin (5 mmol/L) Inhibits Leukocyte Attack and Triggered Reactive Cell Proliferation in a 3D Human Coronary In Vitro Model

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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