Why the study?
Does nitric oxide amplify NO synthase expression in IL-1 beta-stimulated rat mesangial cells?
Population
Rat mesangial cells stimulated with interleukin 1 beta (IL-1 beta)
Comparison
Nitric oxide donors or NO synthesis inhibitors vs IL-1 beta stimulation alone
Design
Preclinical
Authors
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Hypothesis-generating for NO positive feedback in inflammatory cells; human studies needed before therapeutic translation.
Does nitric oxide amplify NO synthase expression in IL-1 beta-stimulated rat mesangial cells?
Nitric oxide functions in a positive feedback loop to amplify its own biosynthesis in IL-1 beta-stimulated rat mesangial cells, which may explain excessive NO formation in inflammatory diseases.
Mühl et al. (1995) studied this question.
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