Circulating oxidized LDL: determinants and association with brachial flow-mediated dilation
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Key result
The oxLDL/apoB100 ratio was significantly and negatively associated with brachial flow-mediated dilation (P=0.017), whereas absolute oxLDL levels and LDL-cholesterol were not.
Population
624 Caucasian men and women, participating in a population-based cohort study. Excluded persons using…
Design
Cohort
Authors
Discussion
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Implication
Supports oxLDL/apoB100 ratio as endothelial marker over absolute levels; hypothesis-generating and requires prospective validation before clinical use.
Study Design
Type
Cross-Sectional (n=624)
Structured PICO
P
Population
624 elderly men and women (aged 50-87 years) from a population-based cohort, free of lipid-lowering medication, evaluated for determinants of oxidized LDL and its association with brachial flow-mediated dilation.
O
Outcome
Flow-mediated dilation (FMD) of the brachial arterysurrogate
Main Result
Effect estimate: beta -14.9 (95% CI -27.2 to -2.7)
p-value: p=0.017
Adjusting oxidized LDL for LDL particle number using apoB100 improves its association with endothelial dysfunction, suggesting it is a more clinically useful marker of atherosclerosis.
Limitations
- Study population was limited to elderly Caucasians, limiting generalizability to other ethnic and age groups.
- Exclusion of subjects using lipid-lowering medication may have led to selection of subjects with a lower cardiovascular risk profile, potentially underestimating associations.
- The assay used specifically detects epitopes of oxidized apoB100, which may not capture all forms of oxLDL.
- Cross-sectional design limits the ability to establish causality between oxidative stress and diminished vasodilation.
- Study population limited to elderly Caucasians
- Exclusion of subjects using lipid-lowering medication may have led to selection of subjects with a low cardiovascular risk profile
- The assay used to measure oxLDL specifically detects epitopes of oxidized apoB100, and assays detecting epitopes on other constituents may yield different results
Cite This Study
Zwan et al. (2008) conducted a cross-sectional in Cardiovascular Risk (n=624). oxLDL/apoB100 ratio was evaluated on Brachial flow-mediated dilation (FMD) (beta -14.9, 95% CI -27.2 to -2.7, p=0.017). The oxLDL/apoB100 ratio was significantly and negatively associated with brachial flow-mediated dilation (P=0.017), whereas absolute oxLDL levels and LDL-cholesterol were not.
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