October 1, 1983Circulation ResearchOpen Access

The oxygen sensitivity of hamster cheek pouch arterioles. In vitro and in situ studies.

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Population

Hamster cheek pouch arterioles (in vitro and in situ models)

Comparison

Removal of parenchyma and exposure to changes in… vs Arterioles with intact parenchyma, and…

Design

Preclinical

Authors

WJWilliam F. JacksonMichigan State University BDBrian R. DulingBoston University

Discussion

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Implication

Challenges necessity of parenchymal mediators for arteriolar O2 sensitivity; extends local mechanism hypothesis but requires in vivo validation.

Structured PICO

Population

Hamster cheek pouch arterioles (in vitro and in situ models)

Intervention

Removal of parenchyma and exposure to changes in Po2 (from 15/20 to 150 mm Hg)

Comparator

Arterioles with intact parenchyma, and comparison between in vitro and in situ conditions

Outcome

Oxygen sensitivity (measured as percentage of arteriolar constriction)surrogate

The study demonstrates that oxygen sensitivity in hamster cheek pouch arterioles does not absolutely require a parenchymally derived mediator and may result from local action on the arteriolar wall or blood.

Cite This Study

Jackson et al. (1983) studied this question.

synapsesocial.com/papers/6a71bdb8ce524a4339c51f2f https://doi.org/10.1161/01.res.53.4.515

View Full Paper

Ask AI

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Implication

Challenges necessity of parenchymal mediators for arteriolar O2 sensitivity; extends local mechanism hypothesis but requires in vivo validation.

The oxygen sensitivity of hamster cheek pouch arterioles. In vitro and in situ studies.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The oxygen sensitivity of hamster cheek pouch arterioles. In vitro and in situ studies.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider