Key result
Post-PCI 24th hour BNP level was an independent predictor of major adverse cardiac events during 12 months of follow-up after elective successful PCI.
Why the study?
Do peri-procedural B-type natriuretic peptide (BNP) levels predict major adverse cardiac events in stable coronary artery disease patients undergoing elective percutaneous coronary intervention?
Cohort (n=95)
Do peri-procedural B-type natriuretic peptide (BNP) levels predict major adverse cardiac events in stable coronary artery disease patients undergoing elective percutaneous coronary intervention?
Elevated BNP levels 24 hours after elective PCI independently predict the occurrence of major adverse cardiac events at 1 year.
Answers are grounded in this paper and cite their sources.
Post-PCI BNP may aid MACE risk stratification after elective PCI; hypothesis-generating and should not yet change practice.
OBJECTIVE: B-type natriuretic peptide (BNP) has diagnostic and prognostic value in a wide variety of cardiac disorders including heart failure and acute coronary syndromes. We aimed to evaluate the prognostic value of baseline and post-procedural BNP levels in predicting major adverse cardiac events (MACE) in stable coronary artery disease (CAD) patients undergoing elective percutaneous coronary intervention (PCI). METHODS: Blood samples for BNP were obtained before, 1 hour and 24 hours after PCI of stable CAD patients who underwent elective PCI for de novo lesions in native coronary arteries. Patients were followed for 12 months for the occurrence of major adverse cardiac events (MACE) including cardiac death, myocardial infarction, hospitalization with angina or repeat revascularization. RESULTS: Among the 95 patients with one-year follow-up data 22 had MACE. Baseline clinical and procedural characteristics of patients with and without MACE were similar. Only EF was significantly lower (P < 0.001) and complex lesion type was significantly more common in patients with MACE (P = 0.012). All measured plasma BNP levels were significantly higher in patients with MACE compared to those free of MACE (baseline P < 0.001, 1st hour P = 0.001 and 24th hour P < 0.001). Multiple logistic regression analysis identified the EF (P = 0.026) and 24th hour BNP (P = 0.002) as independent predictors of MACE. If baseline or post-PCI 1st hour BNP levels were put into analysis instead of post-PCI 24th hour BNP the predictive value of BNP lost its significance (both P > 0.05). CONCLUSION: Post-PCI 24th hour BNP is an independent predictor of MACE during 12 months of follow-up after elective successful PCI.
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Yı́ldı́rı́r et al. (2008) conducted a cohort in Stable coronary artery disease (CAD) (n=95). Post-PCI 24th hour B-type natriuretic peptide (BNP) level was evaluated on Major adverse cardiac events (MACE) including cardiac death, myocardial infarction, hospitalization with angina or repeat revascularization (p=0.002). Post-PCI 24th hour BNP level was an independent predictor of major adverse cardiac events during 12 months of follow-up after elective successful PCI.
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