Key result
Kallikrein gene transfer attenuated gentamicin-induced tubular dilatation, lumenal protein casts, inflammatory cell recruitment, and apoptosis in rats.
Why the study?
Does kallikrein gene transfer prevent gentamicin-induced nephrotoxicity in rats?
Population
Rats injected subcutaneously with gentamicin daily for 10 days
Comparison
Intravenous injection of adenovirus carrying the… vs Control virus
Design
Preclinical
Follow-up
10 days
Authors
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Hypothesis-generating in rat gentamicin nephrotoxicity; leaves open translation of kallikrein gene transfer to clinical use.
Does kallikrein gene transfer prevent gentamicin-induced nephrotoxicity in rats?
Kallikrein gene transfer protects against gentamicin-induced nephrotoxicity in rats by inhibiting inflammatory cell recruitment and apoptosis via suppression of oxidative stress.
Bledsoe et al. (2006) studied Gentamicin-induced nephrotoxicity. Adenovirus carrying the human tissue kallikrein gene vs. Control virus was evaluated on Tubular dilatation, lumenal protein casts, monocyte/macrophage infiltration, MCP-1 expression, and renal cell apoptosis. Kallikrein gene transfer attenuated gentamicin-induced tubular dilatation, lumenal protein casts, inflammatory cell recruitment, and apoptosis in rats.
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