Key result
Reduction in blood pressure variability, alongside effective 24-hour blood pressure control, may predict beneficial effects of treatment on cardiac structure in hypertension.
Why the study?
Does reduction in blood pressure variability along with 24-hour BP control improve regression of subclinical cardiac damage in hypertension?
Does reduction in blood pressure variability along with 24-hour BP control improve regression of subclinical cardiac damage in hypertension?
This editorial highlights the potential importance of reducing blood pressure variability, in addition to absolute BP targets, for regressing target organ damage in hypertension.
The study by Triantafyllidi et al. supports the view that regression of subclinical cardiac damage requires an effective 24-hour blood pressure (BP) control along with a reduction in BP variability and suggests that the assessment of BPV and its modifications during the course of therapy may be an useful approach in predicting the beneficial effects of treatment on cardiac structure. However, some aspects and limitations of this study require caution in drawing firm conclusions. So, further investigation is needed to determine if reduction of BPV is actually associated with a regression in cardiac and extracardiac organ damage to identify which which classes of antihypertensive drugs are most effective in reducing BPV, and to elucidate whether those treatments provide additional clinical benefit, independent of the conventional BP targets.
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Cuspidi et al. (2021) conducted an editorial in Hypertension. Reduction in blood pressure variability was evaluated on Regression of subclinical cardiac damage. Reduction in blood pressure variability, alongside effective 24-hour blood pressure control, may predict beneficial effects of treatment on cardiac structure in hypertension.
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