What question did this study set out to answer?

To assess acute hemodynamic and electrocardiographic responses to graded intravenous doses of amiodarone and establish a dose that preserves left ventricular function without promoting ventricular arrhythmias.

January 1, 2000Journal of Veterinary Internal MedicineOpen Access

Hemodynamic and Electrocardiographic Effects of Graded Doses of Amiodarone in Healthy Dogs Anesthetized with Morphine/Alpha Chloralose

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Why the study?

What are the acute hemodynamic and electrocardiographic effects of graded doses of IV amiodarone in healthy dogs anesthetized with morphine/alpha chloralose?

Key Points

To assess acute hemodynamic and electrocardiographic responses to graded intravenous doses of amiodarone and establish a dose that preserves left ventricular function without promoting ventricular arrhythmias.
Administered incremental intravenous doses of amiodarone to healthy canine models anesthetized using a morphine and alpha-chloralose regimen.
Monitored acute cardiovascular responses, focusing on electrocardiographic parameters and left ventricular mechanical performance.
Evaluated acute cardiovascular tolerance across graded dose tiers to delineate safe intravenous administration thresholds.
Identified dose levels that avoided significant impairment of left ventricular contractile performance while preventing proarrhythmic ventricular events.

Structured PICO

What are the acute hemodynamic and electrocardiographic effects of graded doses of IV amiodarone in healthy dogs anesthetized with morphine/alpha chloralose?

Population

Healthy dogs anesthetized with morphine/alpha chloralose

Intervention

Graded doses of IV amiodarone

Outcome

Acute hemodynamic and electrocardiographic effects, left ventricular function, and tendency for ventricular arrhythmiasurrogate

Discussion

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Implication

May inform IV amiodarone dosing in healthy anesthetized dogs; leaves open translation to clinical patients or diseased hearts.

Cite This Study

Bicer et al. (2000) studied this question.

synapsesocial.com/papers/6a71d44126770c2b8de13e1f https://doi.org/10.1892/0891-6640(2000)014<0090:haeeog>2.3.co;2

View Full Paper

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Hemodynamic and Electrocardiographic Effects of Graded Doses of Amiodarone in Healthy Dogs Anesthetized with Morphine/Alpha Chloralose

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Hemodynamic and Electrocardiographic Effects of Graded Doses of Amiodarone in Healthy Dogs Anesthetized with Morphine/Alpha Chloralose

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider