Population
BALB/c mice, including T cell-deficient athymic nude mice and heterozygote mice with normal T cell function…
Comparison
Reconstitution with spleen cells from… vs Reconstitution with spleen cells from…
Design
Preclinical
Authors
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May inform antigen-specific T-cell mechanisms in murine myocarditis; leaves open translation to human disease or therapy.
Immature but antigen-specific T cells play a critical role in aggravating cardiac injury during viral myocarditis in a murine model.
Kishimoto et al. (1990) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: