Key result
Chemotherapy resulted in complete remission of T-cell acute lymphoblastic leukemia and normalization of cardiac structure and function in a patient presenting with severe myocardial infiltration mimicking hypertrophic cardiomyopathy.
Why the study?
Acute lymphoblastic leukemia with myocardial infiltration presenting as an isolated, reversible hypertrophic cardiomyopathy-like phenotype without typical hematological symptoms is exceptionally rare and poses a major diagnostic challenge.
Population
A 25-year-old man with T-cell acute lymphoblastic leukemia mimicking hypertrophic cardiomyopathy
Design
Case report
Follow-up
After three cycles of chemotherapy
Authors
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May warrant considering T-cell ALL in unexplained hypertrophic cardiomyopathy; hypothesis-generating for reversible cardiac involvement.
Case Report (n=1)
T-cell acute lymphoblastic leukemia can present as a rapidly progressive, hypertrophic cardiomyopathy-mimicking condition that is fully reversible with effective chemotherapy.
Jin et al. (2026) conducted a case report in T-cell acute lymphoblastic leukemia with myocardial infiltration (n=1). Chemotherapy (VDPL, venetoclax+chidamide+azacitidine, mitoxantrone+cytarabine) was evaluated on Complete remission and normalization of cardiac structure and function. Chemotherapy resulted in complete remission of T-cell acute lymphoblastic leukemia and normalization of cardiac structure and function in a patient presenting with severe myocardial infiltration mimicking hypertrophic cardiomyopathy.
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