Key result
Run training for 8 weeks induced a desensitization of the chronotropic response to IB-MECA (potency 5.66 vs 6.10 in sedentary rats) without changing the potency of CPA and NECA.
Why the study?
Does run training alter the chronotropic response to adenosine receptor stimulation in rats?
Population
Rats (right atria from trained and sedentary rats)
Comparison
Run training for 60 min, 5 days a week, over a… vs Sedentary rats
Design
Preclinical
Follow-up
8 weeks
Authors
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Supports exclusion of adenosine receptor mediation in rat training bradycardia; leaves open alternative mechanisms and human translation.
Does run training alter the chronotropic response to adenosine receptor stimulation in rats?
Absolute Event Rate: 5.66% vs 6.1%
Run training induces desensitization of the chronotropic response to IB-MECA without changing the potency of CPA and NECA, excluding adenosine receptors' participation in training-induced bradycardia.
Priviero et al. (2004) studied this question. Run training vs. Sedentary group was evaluated on Potency of IB-MECA (negative chronotropic response). Run training for 8 weeks induced a desensitization of the chronotropic response to IB-MECA (potency 5.66 vs 6.10 in sedentary rats) without changing the potency of CPA and NECA.
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