Why the study?
Does chronic ETA receptor blockade improve flow-induced dilation in resistance arteries of hypertensive rats?
Does chronic ETA receptor blockade improve flow-induced dilation in resistance arteries of hypertensive rats?
Chronic ETA receptor blockade improves endothelium-dependent flow-induced dilation in hypertensive rats independent of blood pressure changes.
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Hypothesis-generating for ETA blockade in hypertensive endothelial dysfunction; human studies required before any clinical consideration.
Iglarz et al. (1998) studied this question.
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