Why the study?
Does prolonged ET(A)-receptor blockade with LU135252 alter vascular reactivity in the aorta of spontaneously hypertensive rats?
Population
Normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs), n=8
Comparison
LU135252 (ET-receptor blocker) 50 mg/kg/day for… vs Untreated controls
Design
Preclinical
Follow-up
2 weeks
Authors
Loading...
ET(A) blockade may modulate endothelial pathways in hypertensive models; leaves open translation to human therapy.
Does prolonged ET(A)-receptor blockade with LU135252 alter vascular reactivity in the aorta of spontaneously hypertensive rats?
Prolonged ET(A)-receptor blockade alters vascular reactivity in hypertensive rats by decreasing NO-dependent dilation and increasing EDHF-dependent dilation.
Iglarz et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: