Population
In vivo adult rat hearts and livers
Comparison
Direct injection of soluble Fas ligand at… vs Liver cells and 0 microg/mL concentration
Design
Preclinical
Follow-up
36 hours
Authors
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Cardiomyocyte resistance to Fas-induced apoptosis warrants no clinical translation; leaves open relevance to human disease models or therapies.
In vivo adult cardiomyocytes are more resistant to Fas ligand-induced apoptosis than liver cells, but exhibit a similarly rapid clearance rate and unique ultrastructural features.
Hayakawa et al. (2002) studied this question.
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