Inhibition of nitric oxide and prostaglandins, but not endothelial‐derived hyperpolarizing factors, reduces blood flow and aerobic energy turnover in the exercising human leg

9 healthy subjects

Intra-arterial infusion of indomethacin (621 +/- 17 microg min(-1)), indomethacin + L-NMMA (12.4 +/- 0.3 mg min(-1)) (double blockade), and indomethacin + L-NMMA + tetraethylammonium chloride (TEA; 12.4 +/- 0.3 mg min(-1)) (triple blockade)

Control (without infusion)

Haemodynamics (leg blood flow, vascular conductance) and plasma ATP at rest and during one-legged knee-extensor exercisesurrogate