January 22, 2011AJP Heart and Circulatory Physiology
Skeletal muscle blood flow and oxygen uptake at rest and during exercise in humans: a pet study with nitric oxide and cyclooxygenase inhibition
Why the study?
Does nitric oxide synthase and cyclooxygenase inhibition alter skeletal muscle blood flow and oxygen uptake at rest and during exercise in healthy males?
Population
Healthy males
Comparison
Arterial infusion of N-monomethyl-L-arginine… vs Control conditions
Design
Other
Authors
Discussion
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Member takes
Implication
Compensatory oxygen extraction may offset reduced muscle blood flow with NOS/COX inhibition during exercise; hypothesis-generating for healthy males and requires confirmation in disease.
Structured PICO
Does nitric oxide synthase and cyclooxygenase inhibition alter skeletal muscle blood flow and oxygen uptake at rest and during exercise in healthy males?
P
Population
Healthy males
I
Intervention
Arterial infusion of N(G)-monomethyl-L-arginine (L-NMMA) alone (nitric oxide synthase inhibition), and combined with indomethacin (cyclooxygenase inhibition)
C
Comparator
Control conditions
O
Outcome
Skeletal muscle blood flow and oxygen uptake at rest and during light knee-extensor exercise, measured by positron emission tomography (PET)surrogate
Inhibition of nitric oxide formation enhances resting muscle oxygen uptake, and combined NOS and COX inhibition during exercise increases muscle oxygen uptake despite reducing blood flow.
Cite This Study
Heinonen et al. (2011) studied this question.