Key result
NOS inhibition with L-NAME did not significantly accelerate muscle VO2 kinetics compared to control (time constant 10.4 vs 10.6 s).
Why the study?
Does NOS inhibition by L-NAME accelerate muscle oxygen uptake kinetics in isolated canine muscle?
Population
Isolated canine gastrocnemius muscles in situ (n = 6)
Comparison
L-NAME (20 mg kg) administered during… vs Control (CTRL) condition without L-NAME
Design
Preclinical
Authors
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NO inhibition does not accelerate VO2 kinetics in canine muscle; leaves open its role in human exercise physiology.
Does NOS inhibition by L-NAME accelerate muscle oxygen uptake kinetics in isolated canine muscle?
Absolute Event Rate: 10.4% vs 10.6%
p-value: p=not significant
NOS inhibition by L-NAME does not accelerate muscle oxygen uptake kinetics at exercise onset in isolated canine muscle, suggesting NO down-regulation of mitochondrial respiration does not limit oxidative metabolism adjustment.
Grassi et al. (2005) studied Muscle oxygen uptake kinetics (n=6). L-NAME vs. Control was evaluated on Time constant (tau(f)) of the 'fundamental' component of VO2 kinetics (p=not significant). NOS inhibition with L-NAME did not significantly accelerate muscle VO2 kinetics compared to control (time constant 10.4 vs 10.6 s).
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