August 1, 2001Journal of Applied Physiology

Effect of l-NAME on oxygen uptake kinetics during heavy-intensity exercise in the horse

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Population

5 geldings (horses)

Comparison

nitro-L-arginine methyl ester (L-NAME) 20 mg/kg vs control (without L-NAME)

Design

Preclinical, order randomized

Authors

CKCasey A. KindigWalsh University PMPaul McDonoughFlorida State University HEHoward H. EricksonCreighton University

Discussion

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Implication

Suggests NO slows VO2 kinetics in equine exercise; hypothesis-generating and leaves open human relevance.

Structured PICO

Population

5 geldings (horses)

Intervention

nitro-L-arginine methyl ester (L-NAME) 20 mg/kg

Comparator

control (without L-NAME)

Outcome

oxygen uptake (VO2) kinetics (time constant of the primary on-kinetic response)surrogate

Inhibition of nitric oxide synthase with L-NAME accelerates oxygen uptake kinetics during heavy-intensity exercise in horses, suggesting NO contributes to metabolic inertia.

Cite This Study

Kindig et al. (2001) studied this question.

synapsesocial.com/papers/6a75dafbfbccc8f4fd1627e4 https://doi.org/10.1152/jappl.2001.91.2.891

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Effect of l-NAME on oxygen uptake kinetics during heavy-intensity exercise in the horse

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of l-NAME on oxygen uptake kinetics during heavy-intensity exercise in the horse

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider