Key result
Systemic infusion of L-NAME reduced the phase II VO2 time constant by 44% compared to saline control during supra-maximal exercise (20.4 vs 36.3 s; P=0.01).
Why the study?
Does systemic infusion of L-NAME improve pulmonary O2 uptake kinetics during supra-maximal exercise in healthy young men?
Population
7 healthy young men
Comparison
Systemic infusion of N-nitro-L-arginine methyl… vs 50 ml saline infusion prior to the same exercise…
Design
Other
Authors
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Hypothesis-generating for faster VO2 kinetics with NOS inhibition in healthy subjects; should not yet change practice.
Does systemic infusion of L-NAME improve pulmonary O2 uptake kinetics during supra-maximal exercise in healthy young men?
Absolute Event Rate: 20.4% vs 36.3%
p-value: p=0.01
Nitric oxide synthase inhibition with L-NAME accelerates oxidative metabolism following the onset of supra-maximal exercise in healthy humans.
Wilkerson et al. (2004) studied Healthy (n=7). L-NAME vs. 50 ml saline was evaluated on phase II VO2 time constant (p=0.01). Systemic infusion of L-NAME reduced the phase II VO2 time constant by 44% compared to saline control during supra-maximal exercise (20.4 vs 36.3 s; P=0.01).
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