October 1, 1998AJP Heart and Circulatory Physiology

Effects of isoflurane on Ca2+i, SR Ca2+content, and twitch force in intact trabeculae

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Population

Intact rat ventricular trabeculae

Comparison

Isoflurane vs Lowering extracellular [Ca2+], adding…

Design

Preclinical

Authors

YJYandong JiangResearch Institute of Petroleum Exploration and Development FJFred J. JulianHarvard University Press

Discussion

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Implication

Isoflurane's Ca2+ effects in animal myocardium are hypothesis-generating; leaves open human translation and clinical relevance.

Structured PICO

Population

Intact rat ventricular trabeculae

Intervention

Isoflurane

Comparator

Lowering extracellular [Ca2+], adding 2,3-butanedione monoxime, or halothane

Outcome

Intracellular Ca2+ transient ([Ca2+]i), sarcoplasmic reticulum (SR) Ca2+ content, and twitch forcesurrogate

Isoflurane depresses myocardial contractility through a combination of reducing the intracellular calcium transient and altering sarcoplasmic reticulum calcium release.

Cite This Study

Jiang et al. (1998) studied this question.

synapsesocial.com/papers/6a71f15a2163a0a01bc5dc74 https://doi.org/10.1152/ajpheart.1998.275.4.h1360

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Effects of isoflurane on Ca2+i, SR Ca2+content, and twitch force in intact trabeculae

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of isoflurane on Ca2+i, SR Ca2+content, and twitch force in intact trabeculae

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider