In frog atrial muscle, ryanodine maintains the open state of SR Ca2+-release channels only when triggered by SR Ca2+ release agents like caffeine, supporting the notion that SR Ca2+ release is not a major source of Ca2+ during the normal frog heart beat.
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Ryanodine's state-dependent SR inhibition in frog atrium does not inform clinical practice; leaves open generalization to mammalian excitation-contraction coupling.
Tunstall et al. (1994) studied this question.
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