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January 19, 2021Prenatal DiagnosisOpen Access

Late gestation predictors of a postnatal biventricular circulation after fetal aortic valvuloplasty

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Why the study?

Predicting which fetuses will achieve a biventricular circulation after fetal aortic valvuloplasty remains challenging, and late gestation echocardiographic predictors could improve parental counseling.

Do specific late gestation echocardiographic parameters predict postnatal biventricular circulation in fetuses undergoing fetal aortic valvuloplasty for severe aortic stenosis?

Population

96 liveborn patients who underwent fetal aortic valvuloplasty with late gestation echocardiography available

Design

Cohort study

Follow-up

Neonatal discharge

Authors

MBMeaghan BeattieLucile Packard Children's HospitalKFKevin G. FriedmanBoston University
Lynn A. Sleeper
Lynn A. SleeperPediatric / Congenital Cardiology

Discussion

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Implication

Late-gestation echo predictors may refine BiV counseling after FAV; leaves open prospective validation before wider adoption.

Structured PICO

Do specific late gestation echocardiographic parameters predict postnatal biventricular circulation in fetuses undergoing fetal aortic valvuloplasty for severe aortic stenosis?

P
Population
96 liveborn patients who underwent fetal aortic valvuloplasty (FAV) for severe aortic stenosis (AS) and had late gestation echocardiography available (treated between 2000-2017).
I
Intervention
Fetal aortic valvuloplasty (FAV) followed by late gestation echocardiography assessment
O
Outcome
Biventricular (BiV) circulation at the time of neonatal dischargehard clinical

Late gestation echocardiographic parameters, including LV long axis z-score and anterograde aortic arch flow, independently predict the achievement of a postnatal biventricular circulation after fetal aortic valvuloplasty.

Cite This Study

Beattie et al. (2021) studied this question.

synapsesocial.com/papers/6a71f7485d37378ac1deeef0https://doi.org/10.1002/pd.5885
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Changes in left heart hemodynamics after technically successful in‐utero aortic valvuloplasty2007 · 96 citations
  2. 2Early hemodynamic changes after fetal aortic stenosis valvuloplasty predict biventricular circulation at birth2018 · 37 citations
  3. 3Natural history of 107 cases of fetal aortic stenosis from a European multicenter retrospective study2016 · 87 citations
  4. 4Natural history and outcome of aortic stenosis diagnosed prenatally.1997 · 190 citations
  5. 5Factors affecting technical success of fetal aortic valve dilation2006 · 74 citations