Key result
Among fetuses with aortic stenosis meeting criteria for emerging hypoplastic left heart syndrome, 33% achieved a sustained biventricular circulation without fetal intervention.
Population
107 fetuses with aortic stenosis in ongoing pregnancies that did not undergo fetal valvuloplasty, from a…
Design
Cohort
Follow-up
median 6 years
Authors
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May support refining fetal valvuloplasty criteria; leaves open predictors of biventricular outcome in observational data.
Observational (n=107)
Yes
A substantial proportion of fetuses with aortic stenosis meeting criteria for emerging HLHS achieve biventricular circulation without fetal intervention, indicating a need to refine selection criteria for fetal valvuloplasty.
Gardiner et al. (2016) conducted an observational in fetal aortic stenosis (n=107). Fetal aortic stenosis without fetal intervention was evaluated on Natural history and postnatal circulation outcomes (biventricular, univentricular, or conversion). Among fetuses with aortic stenosis meeting criteria for emerging hypoplastic left heart syndrome, 33% achieved a sustained biventricular circulation without fetal intervention.
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