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May 1, 1987British journal of surgery

Effects of epidural administration of local anaesthetics or morphine on postoperative nitrogen loss and catabolic hormones

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Why the study?

Does epidural analgesia with local anaesthetics or morphine reduce postoperative nitrogen loss and catabolic hormone responses in patients undergoing elective gastrectomy?

Population

Patients undergoing elective gastrectomy

Comparison

Prolonged epidural analgesia with local… vs General anaesthesia with postoperative pain…

Design

Cohort

Follow-up

3 days postoperatively

Authors

HTHideo TsujiNational Institute of GeneticsCSC ShirasakaKyushu UniversityTAT AsohOita University Hospital

Discussion

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Implication

May reduce postoperative nitrogen loss after gastrectomy; hypothesis-generating and requires randomized confirmation before practice change.

Structured PICO

Does epidural analgesia with local anaesthetics or morphine reduce postoperative nitrogen loss and catabolic hormone responses in patients undergoing elective gastrectomy?

P
Population
Patients undergoing elective gastrectomy
I
Intervention
Prolonged epidural analgesia with local anaesthetics during and after surgery (Group PE) or epidural analgesia intra-operatively and epidural morphine postoperatively (Group EM)
C
Comparator
General anaesthesia with postoperative pain relieved by intermittent injections of analgesics (Group G)
O
Outcome
Urinary excretion of nitrogen during the first three postoperative dayssurrogate

Epidural analgesia with local anaesthetics or morphine reduces postoperative nitrogen loss and catabolic hormone responses compared to general anaesthesia with intermittent systemic analgesics.

Cite This Study

Tsuji et al. (1987) studied this question.

synapsesocial.com/papers/6a71fac2e36a167817e398efhttps://doi.org/10.1002/bjs.1800740536
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Blocking Effect of Epidural Analgesia on the Adrenocortical and Hyperglycemic Responses to Surgery1977 · 244 citations
  2. 2Effect of Epidural Analgesia on Glucose Tolerance During Surgery1980 · 21 citations
  3. 3Attenuation of adrenocortical response to upper abdominal surgery with epidural blockade1983 · 37 citations
  4. 4Epidural analgesia improves postoperative nitrogen balance.1978 · 167 citations
  5. 5Role of the splanchnic nerves in endocrine and metabolic response to abdominal surgery1986 · 37 citations