Population
Isolated papillary muscles of the guinea pig and the rat
Comparison
Propofol and thiamylal vs Intralipid alone
Design
Preclinical
Authors
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Species differences in myocardial responses to anesthetics urge caution extrapolating to humans; leaves open validation across models before clinical inference.
Propofol and thiamylal exhibit species-specific differences in their inotropic and electrophysiologic effects on isolated ventricular myocardium, likely due to differential effects on calcium and potassium currents.
Azuma et al. (1993) studied this question.
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