Why the study?
Does mineralocorticoid modulation alter the exaggerated natriuresis in spontaneously hypertensive rats compared to normotensive rats?
Population
Spontaneously hypertensive and normotensive rats
Comparison
Treatment with spironolactone or D-aldosterone… vs Control salt load without mineralocorticoid…
Design
Preclinical
Authors
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Implicates relative aldosterone deficiency in exaggerated natriuresis of hypertensive rat models; hypothesis-generating for human salt handling and should not change practice.
Does mineralocorticoid modulation alter the exaggerated natriuresis in spontaneously hypertensive rats compared to normotensive rats?
Exaggerated natriuresis in spontaneously hypertensive rats appears to be mediated by a relative lack of aldosterone-mediated distal tubular sodium reabsorption.
Willis et al. (1978) studied this question.
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