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July 1, 1993The Journal of ImmunologyOpen Access

Induction of transforming growth factor- beta during cardiac allograft rejection.

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Population

Rat cardiac allograft transplant model

Comparison

Cardiac allograft transplantation vs Normal control hearts

Design

Preclinical

Follow-up

up to 6 months

Authors

JWJohannes WaltenbergerInterventional CardiologyAWAlkwin WandersAalborg University HospitalBFB FellströmUppsala University

Discussion

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Implication

TGF-beta upregulation may represent a rejection target; rat allograft data leaves open translation to human cardiac transplantation.

Structured PICO

P
Population
Rat cardiac allograft transplant model
I
Intervention
Cardiac allograft transplantation (evaluated during acute rejection up to 6 days and chronic rejection up to 6 months with cyclosporin A immunosuppression)
C
Comparator
Normal control hearts
O
Outcome
Expression and bioactivity of TGF-beta 1, TGF-beta 2, TGF-beta 3, and latent TGF-beta binding protein (LTBP)surrogate

Highly elevated levels of TGF-beta and LTBP during chronic rejection of cardiac allografts in rats suggest a potential counter-regulatory mechanism that could be targeted for preventing allograft rejection.

Cite This Study

Waltenberger et al. (1993) studied this question.

synapsesocial.com/papers/6a72094bf44fa9f079dfa6cdhttps://doi.org/10.4049/jimmunol.151.2.1147
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PDGF-A, -C, and -D but not PDGF-B Increase TGF-β1 and Chronic Rejection in Rat Cardiac Allografts2009 · 51 citations
  2. 2The Expression Of Acidic Fibroblast Growth Gactor (Heparin-Binding Growth Factor-1) And Cytokine Genes In Human Cardiac Allografts And T Cells1993 · 44 citations
  3. 3Immune Sources of Transforming Growth Factor-β 1 Reduce Transplant Arteriosclerosis1998 · 37 citations
  4. 4Cytokine gene expression in human cardiac allograft recipients1994 · 27 citations
  5. 5LOCAL PRODUCTION OF CYTOKINES IN THE HUMAN CARDIAC ALLOGRAFT1994 · 78 citations