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May 23, 2014Circulation Heart FailureOpen Access

The Gut Hormone Ghrelin Partially Reverses Energy Substrate Metabolic Alterations in the Failing Heart

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Why the study?

Does acute infusion of des-acyl or acyl ghrelin improve cardiac energy substrate metabolism in dogs with pacing-induced heart failure?

Population

14 chronically instrumented dogs (8 with pacing-induced heart failure and 6 normal controls)

Comparison

Intravenous infusion of human des-acyl ghrelin… vs Baseline measurements and normal control dogs

Design

Preclinical

Follow-up

15 minutes per infusion

Authors

GMGianfranco MitacchioneJPJeffrey C. PowersGGGino Grifoni

Discussion

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Overview

Hypothesis-generating for ghrelin in HF metabolism; human trials needed before any clinical consideration.

Structured PICO

Does acute infusion of des-acyl or acyl ghrelin improve cardiac energy substrate metabolism in dogs with pacing-induced heart failure?

P
Population
14 chronically instrumented dogs (8 with pacing-induced heart failure and 6 normal controls)
I
Intervention
Intravenous infusion of human des-acyl ghrelin (1.2 nmol/kg per hour) for 15 minutes, followed by washout and infusion of acyl ghrelin at the same dose
C
Comparator
Baseline measurements and normal control dogs
O
Outcome
Cardiac free fatty acid and glucose oxidation and lactate uptakesurrogate

Acute infusion of ghrelin partially reverses the metabolic shift in failing hearts by enhancing free fatty acid oxidation and reducing glucose oxidation.

Cite This Study

Mitacchione et al. (2014) studied this question.

synapsesocial.com/papers/6a720a5e26770c2b8de15016https://doi.org/10.1161/circheartfailure.114.001167
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