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October 1, 1996Hypertension

Impairment of Endothelium-Dependent Relaxation by Increasing Percentages of Glycosylated Human Hemoglobin

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Why the study?

Does glycosylated human hemoglobin impair endothelium-dependent relaxation in rat aortic segments?

Population

Rat aortic segments

Comparison

Preincubation with increasing percentages of… vs Control conditions

Design

Preclinical

Authors

JAJavier AnguloInstituto Ramón y Cajal de Investigación SanitariaCSCarlos F. Sánchez‐FerrerHospital Universitario La PazCPConcepción PeiróUniversidad Autónoma de Madrid

Discussion

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Implication

Glycosylated hemoglobin may impair endothelial function via superoxide in hyperglycemia; animal data leave open relevance to human hypertension.

Structured PICO

Does glycosylated human hemoglobin impair endothelium-dependent relaxation in rat aortic segments?

P
Population
Rat aortic segments
I
Intervention
Preincubation with increasing percentages of glycosylated human hemoglobin (1 and 10 nmol/L, up to 14% glycosylation)
C
Comparator
Control conditions
O
Outcome
Endothelium-dependent relaxations caused by acetylcholinesurrogate

Glycosylated human hemoglobin at levels of 9% or higher impairs endothelium-dependent relaxation by interfering with endothelial nitric oxide via superoxide anion production.

Cite This Study

Angulo et al. (1996) studied this question.

synapsesocial.com/papers/6a7210b0febe604dd70a6bcfhttps://doi.org/10.1161/01.hyp.28.4.583
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