Why the study?
Does insulin stimulate muscle blood flow by a direct action at the vasculature or by stimulating neural vasodilator mechanisms in humans?
Population
Patients with regional sympathectomy
Comparison
2-hour insulin/glucose clamp, with infusion of… vs Innervated limbs and baseline
Design
Other
Follow-up
2 hours
Authors
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Insulin's direct vascular effects merit mechanistic study in metabolic disease; hypothesis-generating and should not yet change practice.
Does insulin stimulate muscle blood flow by a direct action at the vasculature or by stimulating neural vasodilator mechanisms in humans?
Insulin stimulates muscle blood flow via direct NO-mediated vascular action, an effect that is normally masked by sympathetic vasoconstrictor tone.
Sartori et al. (1999) studied this question.
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