Population
Cultured rat proximal tubule cells on permeable, collagen-coated supports
Comparison
Apical or basolateral angiotensin II incubation… vs Control conditions
Design
Preclinical
Authors
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Does not yet alter hypertension management; leaves open whether endocytosis-dependent AII signaling operates in human kidney disease.
In cultured rat proximal tubule cells, apical angiotensin II activates phospholipase C via type 1 receptors, a process requiring cytoskeleton-dependent endocytosis.
Schelling et al. (1992) studied this question.
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