Key result
Angiotensin II-dependent proximal tubule sodium transport in cultured rat cells was transduced by phospholipase C and adenylyl cyclase, with the adenylyl cyclase effect mediated by phospholipase C.
Population
Rat proximal tubule cells cultured on permeable supports
Comparison
Apical Angiotensin II with or without inhibitors vs Control conditions without inhibitors
Design
Preclinical
Authors
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No immediate clinical implications from rat cell findings; leaves open translation to human proximal tubule function.
Angiotensin II-dependent proximal tubule sodium transport in cultured cells is transduced by phospholipase C and adenylyl cyclase, with the adenylyl cyclase effect mediated by phospholipase C.
Schelling et al. (1994) studied this question. Angiotensin II was evaluated on Unidirectional (AP to basolateral) 22Na flux. Angiotensin II-dependent proximal tubule sodium transport in cultured rat cells was transduced by phospholipase C and adenylyl cyclase, with the adenylyl cyclase effect mediated by phospholipase C.
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