February 1, 1977Annals of Neurology
Suppression of essential tremor by propranolol: Correlation of effect with drug plasma levels and intensity of beta‐adrenergic blockade
Why the study?
Does intravenous propranolol reduce tremor amplitude in adult patients with essential tremor?
Population
6 adult patients with essential tremor
Design
Case_series
Authors
Discussion
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Member takes
Implication
May support IV propranolol for essential tremor; hypothesis-generating and requires randomized confirmation.
Structured PICO
Does intravenous propranolol reduce tremor amplitude in adult patients with essential tremor?
P
Population
6 adult patients with essential tremor
I
Intervention
Propranolol administered intravenously using a bolus-infusion regimen
O
Outcome
Tremor amplitude and frequency in the outstretched handsurrogate
Propranolol suppresses essential tremor amplitude in a dose-dependent manner correlated with plasma levels and beta-adrenergic blockade intensity.
Cite This Study
McAllister et al. (1977) studied this question.