June 14, 2013PLoS ONEOpen Access

Aerobic Interval Training Partly Reverse Contractile Dysfunction and Impaired Ca2+ Handling in Atrial Myocytes from Rats with Post Infarction Heart Failure

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Why the study?

Does aerobic interval training improve atrial myocyte contractile function and Ca2+ handling in rats with post-infarction heart failure?

Population

Female Sprague Dawley rats with post-infarction heart failure, n=27.

Comparison

Aerobic interval training. vs Sedentary HF rats and sedentary sham-operated…

Design

Preclinical, Rats were randomized to either sham operation or myocardial…

Follow-up

8 weeks

Authors

AJAnne Berit JohnsenNorwegian University of Science and Technology MHMorten A. HøydalNorwegian University of Science and Technology RRRagnhild RøsbjørgenNorwegian University of Science and Technology

Discussion

Member takes

Implication

Should not change practice; hypothesis-generating for atrial benefits of interval training in human HF.

Structured PICO

Does aerobic interval training improve atrial myocyte contractile function and Ca2+ handling in rats with post-infarction heart failure?

Population

Female Sprague Dawley rats with post-infarction heart failure (infarct size >40% induced by left coronary artery ligation), n=27 (9 HF-trained, 9 HF-sedentary, 9 sham-sedentary).

Intervention

Aerobic interval training (uphill treadmill running, alternating 4 min at 85-90% VO2max and 2 min at 50% VO2max for 60 min/day, 5 days/week, for 8 weeks).

Comparator

Sedentary HF rats and sedentary sham-operated rats.

Outcome

Atrial myocyte contractile function (fractional shortening, time to relaxation) and Ca2+ handling (Ca2+ amplitude, SR Ca2+ content, Ca2+ transient decay, SERCA2a activity, NCX activity, diastolic Ca2+ leak).surrogate

High-intensity aerobic interval training partially reverses atrial myocyte contractile dysfunction and impaired calcium handling in a rat model of post-infarction heart failure.

Limitations

Atrial fibrillation was not characterized in the HF-rat model

Cite This Study

Johnsen et al. (2013) studied this question.

synapsesocial.com/papers/6a721e6b6ceb2bbd16e04d0b https://doi.org/10.1371/journal.pone.0066288

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Aerobic Interval Training Partly Reverse Contractile Dysfunction and Impaired Ca2+ Handling in Atrial Myocytes from Rats with Post Infarction Heart Failure

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Aerobic Interval Training Partly Reverse Contractile Dysfunction and Impaired Ca2+ Handling in Atrial Myocytes from Rats with Post Infarction Heart Failure

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

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Also Consider