Why the study?
Does amlodipine monotherapy affect the serum lipid profile in hypertensive patients?
Does amlodipine monotherapy affect the serum lipid profile in hypertensive patients?
Amlodipine monotherapy does not adversely affect the lipid profile in hypertensive patients, making it a suitable option for those with underlying hyperlipidemia.
Amlodipine may not alter lipids in this hypertensive cohort; leaves open randomized confirmation before practice implications.
Objectives: To assess the effect of amlodipine, as monotherapy, in hypertensive patients, on serum lipid profile, as assessed by serum cholesterol, serum triglyceride, high density lipoprotein cholesterol (HDLC), and low density lipoprotein cholesterol (LDLC).Subjects and methods: Thirty three hypertensive patients were included in the study, 25 of them were males and 8 were females. Serum cholesterol, triglyceride, HDLC and LDLC were measured before and after 2 months of starting treatment with amlodipine.Results: No significant difference could be found between the pre and post treatment levels of all measured parameters.Conclusion: Treatment with amlodipine does not produce deleterious effect on lipid profile, so it may be a suitable therapy in a hypertensive patient with underlying hyperlipidaemia.
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Al-Hayali et al. (2009) studied this question.
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