Key result
Enalapril and amlodipine improved lipid profiles in newly diagnosed hypertensive men, whereas atenolol and hydrochlorothiazide significantly increased triglycerides and VLDL-C after 8 weeks.
Why the study?
Do different classes of antihypertensive therapy differentially affect serum lipids in newly diagnosed male essential hypertensive patients?
RCT (n=99)
Randomly allocated
Do different classes of antihypertensive therapy differentially affect serum lipids in newly diagnosed male essential hypertensive patients?
Different antihypertensive classes have divergent effects on lipid profiles, with enalapril and amlodipine showing favorable effects while atenolol and hydrochlorothiazide adversely affect lipids.
Clinicians should weigh lipid effects when choosing antihypertensives for men; extends RCT evidence on class-specific metabolic impacts.
The effect of antihypertensives on serum lipids in newly diagnosed male essential hypertensive patients was studied. The participants (n = 99) were randomly allocated to receive amlodipine, atenolol, enalapril, hydrochlorothiazide, and a combination of amlodipine and atenolol. Lipid parameters were estimated before and after 8 weeks of therapy. The atenolol and thiazide group showed a significant increase in triglycerides (TGs) and very-low-density lipoprotein cholesterol (VLDL-C). High-density lipoprotein cholesterol (HDL-C) and HDL-C to low-density lipoprotein cholesterol (LDL-C) ratio were significantly increased and TC to HDL-C ratio was significantly decreased in the amlodipine and amlodipine- atenolol combination groups. In the enalapril group, we found a significant reduction in TC, TGs, VLDL-C, non-HDL-C, and TG to HDL-C ratio after treatment. It can be concluded from the present study that some drugs have beneficial effects on the lipid status, whereas others adversely affect the lipid status in hypertension.
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Nandeesha et al. (2008) conducted an RCT in Essential hypertension (n=99). Amlodipine, atenolol, enalapril, hydrochlorothiazide, and amlodipine-atenolol combination vs. Active comparators (each other) was evaluated on Serum lipid parameters. Enalapril and amlodipine improved lipid profiles in newly diagnosed hypertensive men, whereas atenolol and hydrochlorothiazide significantly increased triglycerides and VLDL-C after 8 weeks.
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