Key result
Atenolol, enalapril, and amlodipine all significantly reduced systolic and diastolic blood pressure over 3 months, while amlodipine uniquely reduced LDL cholesterol and enalapril increased HDL cholesterol.
Why the study?
The study was conducted to compare the effects of atenolol, enalapril, and amlodipine on blood pressure, heart rate, and serum lipid profiles in hypertension.
Do different antihypertensive drugs (atenolol, enalapril, amlodipine) have differing effects on blood pressure, heart rate, and lipid profiles in patients with hypertension?
RCT (n=300)
Randomly allocated
No
Do different antihypertensive drugs (atenolol, enalapril, amlodipine) have differing effects on blood pressure, heart rate, and lipid profiles in patients with hypertension?
All three agents lower BP with distinct HR and lipid effects; leaves open individualized selection by comorbidities in larger trials.
Background : Hypertension (HTN) is a chronicmedical condition in which the systemic arterial bloodpressure is elevated. AIM OF STUDTY: The present study compared the effects of atenolol, enalapril andamlodipine on diastolic and systolic pressure & heart rate in hypertension and effects on serum lipid werealso assessed.Patients and Method: A total of 200 patients with hypertension and 100 normotensive controls. Thehypertensive patients were randomly allocated into three groups each of 100 patients and were treated witheither atenolol (50-100 mg) or enalapril (10-20mg) or amlodipine (5-10 mg) for three months.Results: Patients taking atenolol showed a significant reduction of SBP, heart rate, while the group takingenalapril showed a significant reduction of SBP, DBP, and no significant change in heart rate while withamlodipine showed a significant decreases of SBP, DBP whereas the change in heart rate was not significanton ther hand Amlodipine was significantly better than atenolol and enalapril at reducing total cholesterollevel. Amlodipine was significantly better than atenolol and enalapril at reducing LDL cholesterol level.Enalapril was significantly better than amlodipine and atenolol at increasing serum HDL level . DiscussionIn this study There was no significant change in heart rate in patients taking, enalapril, or amlodipine whilethe heart rate was significantly reduced by atenolol. On other hand the enalapril treated group a significantincrease of HDL cholesterol. The favorable lipid changes observed with a mlodipine, a signifcant decreasesof total cholesterol and LDL cholesterol levels.Conclusions: The systolic and diastolic BP values were significantly reduced after, atenolol, enalapril, oramlodipine therapy . There was no significant change in heart rate in patients taking, enalapril, or amlodipinewhich is consistent with that reported else On the other hand heart rate was significantly reduced by atenolol. on other hand amlodipine are to be preferred in hypertensive patients with elevated LDL-cholesterol levelsand enalapril is valuable in hypertensive patients with low HDL-cholesterol levels.
No takes yet. Share an insight, caveat, or question.
Khalid I. Hussein (2020) conducted an RCT in Mild-moderate hypertension (n=300). Atenolol, Enalapril, or Amlodipine vs. Normotensive controls and active comparators was evaluated on Systolic and diastolic blood pressure. Atenolol, enalapril, and amlodipine all significantly reduced systolic and diastolic blood pressure over 3 months, while amlodipine uniquely reduced LDL cholesterol and enalapril increased HDL cholesterol.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: