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Flow mediated dilation is a non-invasive ultrasound technique that inversely correlates with cardiovascular risk, but requires strict standardization and larger reference cohorts before routine clinical implementation.
Endotel je bariĂŠrou mezi krevnĂm a cĂŠvnĂm kompartmentem, kterĂ˝ mĂĄ Ĺadu unikĂĄtnĂch funkcĂ. ZajiĹĄĹĽuje mechanickou ochranu, transport Ĺady molekul napĹĂÄ cĂŠvnĂ stÄnou, optimalizuje prĹŻtok krve tkĂĄnÄmi, zĂĄsadnÄ ovlivĹuje imunitnĂ dÄje a jinĂŠ. Jeho dysfunkce mĂĄ proto dramatickĂ˝ vliv dalĹĄĂ prognĂłzu pacienta. Flow mediated dilation (FMD) je jednoduchĂ˝ test zaloĹženĂ˝ na stanovenĂ mĂry vazodilatace vybranĂŠ tepny (nejÄastÄji arteria brachialis) vyvolanĂŠ zvýťenĂ˝m krevnĂm prĹŻtokem. Ĺada studiĂ prokĂĄzala, Ĺže vztah kardiovaskulĂĄrnĂho rizika a FMD mĂĄ inverznĂ charakter. KromÄ svojĂ jednoduchosti mĂĄ ovĹĄem i Ĺadu nevĂ˝hod, napĹ. pĹesnost a zejmĂŠna nedostateÄnĂ˝ referenÄnĂ soubor. Po jejich pĹekonĂĄnĂ je pravdÄpodobnĂŠ, Ĺže test FMD lze pouĹžĂt k upĹesnÄnĂ kardiovaskulĂĄrnĂho rizika.
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Biel et al. (2019) studied this question.
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