Why the study?
African swine fever causes up to 100% mortality and lacks commercial vaccines or antiviral drugs outside Vietnam, making virus attenuation via serial passage a key approach for vaccine development.
The cell-adapted ASFV HLJ18/BK33 is highly attenuated but fails to provide immune protection against the parental virulent virus in pigs.
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Attenuated ASFV strain may aid safer lab studies; leaves open vaccine efficacy and field use in swine.
Wang et al. (2025) studied this question.
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