Key result
Progressive passage of African swine fever virus in Vero cells led to complete attenuation in swine by passage 110, but the attenuated virus failed to confer protection against virulent challenge.
Adaptation of ASFV-G to Vero cells leads to complete attenuation in swine but fails to confer protective immunity against the virulent parental strain.
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Attenuated ASFV via Vero passage fails to protect swine; leaves open whether alternative attenuation strategies can yield effective vaccines.
Krug et al. (2014) studied African swine fever. ASFV-G passaged in Vero cells vs. Virulent parental ASFV-G was evaluated on Virulence in swine and protection against challenge. Progressive passage of African swine fever virus in Vero cells led to complete attenuation in swine by passage 110, but the attenuated virus failed to confer protection against virulent challenge.
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