Why the study?
African swine fever is a devastating disease of pigs needing worldwide control measures, but conventional virus culture in primary porcine macrophages is challenging regarding scalability, cost, and biosafety.
Continuous cell lines offer a scalable and economical alternative to primary porcine macrophages for African swine fever virus propagation and live attenuated vaccine development.
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Advances in ASFV culture systems may accelerate vaccine development; leaves open scalable, biosafe translation to licensed products.
Chailangkarn et al. (2025) studied this question.
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