Key result
Infection of pigs with a continuous cell culture-adapted variant of African swine fever virus resulted in 16.7% lethality, with surviving animals becoming resistant to virulent reinfection.
Adaptation of ASFV to continuous cell culture resulted in a variant with reduced lethality (16.7%) that conferred resistance to virulent reinfection, associated with a 3,000 bp genomic deletion.
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Attenuated ASFV variant may protect swine from virulent challenge; leaves open vaccine translation pending controlled field trials.
Mazloum et al. (2019) studied African swine fever virus infection. Adapted variant ASFV Odintsovo 02/14 isolate (30th passage) was evaluated on Lethality level. Infection of pigs with a continuous cell culture-adapted variant of African swine fever virus resulted in 16.7% lethality, with surviving animals becoming resistant to virulent reinfection.
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